טיפול באוזון: פתרונות חדשניים למחלות עור

1. Boer M, Duchnik E, Maleszka R, Marchlewicz M. Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function. Postepy Dermatologii i Alergologii. 2016;33(1):1‐5. [DOI] [PMC free article] [PubMed] [Google Scholar]

2. Wolff S. Aspects of the adaptive response to very low doses of radiation and other agents. Mutat Res. 1996;358(2):135‐142. [DOI] [PubMed] [Google Scholar]

3. Hidalgo‐Tallon FJ, Torres‐Morera LM, Baeza‐Noci J, Carrillo‐Izquierdo MD, Pinto‐Bonilla R. Updated review on ozone therapy in pain medicine. Front Physiol. 2022;13:194. [DOI] [PMC free article] [PubMed] [Google Scholar]

4. Ezeldin M, Leonardi M, Princiotta C, et al. Percutaneous ozone nucleolysis for lumbar disc herniation. Neuroradiology. 2018;60(11):1231‐1241. [DOI] [PMC free article] [PubMed] [Google Scholar]

5. Liu J, Zhang P, Tian J, et al. Ozone therapy for treating foot ulcers in people with diabetes. Cochrane Database Syst Rev. 2015;10:CD008474. [DOI] [PMC free article] [PubMed] [Google Scholar]

6. Li Y, Feng X, Ren H, Huang H, Wang Y, Yu S. Low‐dose ozone therapy improves sleep quality in patients with insomnia and coronary heart disease by elevating serum BDNF and GABA. Bull Exp Biol Med. 2021;170(4):493‐498. [DOI] [PubMed] [Google Scholar]

7. Lu J, Guo M, Ligui H, et al. Efficacy of combination of ozonated water with oil for treatment of tinea pedis. Zhong nan da xue xue bao. Yi Xue Ban = J Cent South Univ Med Sci. 2018;43(2):147‐151. [DOI] [PubMed] [Google Scholar]

8. Huang J, Huang J, Xiang Y, Gao L, Pan Y, Lu J. Topical ozone therapy: an innovative solution to patients with herpes zoster. Zhong nan da xue xue bao. Yi Xue Ban = J Cent South Univ Med Sci. 2018;43(2):168‐172. [DOI] [PubMed] [Google Scholar]

9. Zeng J, Lei L, Zeng Q, et al. Ozone therapy attenuates NF‐kappa B‐mediated local inflammatory response and activation of Th17 cells in treatment for psoriasis. Int J Biol Sci. 2020;16(11):1833‐1845. [DOI] [PMC free article] [PubMed] [Google Scholar]

10. Gao L, Dou J, Zhang B, et al. Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63‐mediated transcription of KRT10 to improve psoriasis. J Cell Mol Med. 2020;24(8):4819‐4829. [DOI] [PMC free article] [PubMed] [Google Scholar]

11. Zeng J, Dou J, Gao L, et al. Topical ozone therapy restores microbiome diversity in atopic dermatitis. Int Immunopharmacol. 2020;80:106191. [DOI] [PubMed] [Google Scholar]

12. Jiang F, Deng D, Li X, et al. Curative effect of ozone hydrotherapy for pemphigus. Zhong nan da xue xue bao. Yi Xue Ban = J Cent South Univ Med Sci. 2018;43(2):152‐156. [DOI] [PubMed] [Google Scholar]

13. Rowen RJ. Remission of aggressive autoimmune disease (dermatomyositis) with removal of infective jaw pathology and ozone therapy: review and case report. Autoimmunity Highlights. 2018;9(1):7. [DOI] [PMC free article] [PubMed] [Google Scholar]

14. Borges GA, Elias ST, Mazutti da Silva SM, et al. In vitro evaluation of wound healing and antimicrobial potential of ozone therapy. J Craniomaxillofac Surg. 2017;45(3):364‐370. [DOI] [PubMed] [Google Scholar]

15. Dhamnaskar S, Gobbur N, Koranne M, Vasa D. Prospective comparative observational study of safety and efficacy of topical ozone gas therapy in healing of diabetic foot ulcers versus only conventional wound management. Surg J. 2021;7(3):E226‐E236. [DOI] [PMC free article] [PubMed] [Google Scholar]

16. Peker K, Yilmaz I, Demiryilmaz I, et al. The effect of ozone treatment on thermal burn wound healing; an experimental study. Konuralp Tip Dergisi. 2020;12(3):511‐518. [Google Scholar]

17. Valacchi G, Sticozzi C, Zanardi I, et al. Ozone mediators effect on “in vitro” scratch wound closure. Free Radic Res. 2016;50(9):1022‐1031. [DOI] [PubMed] [Google Scholar]

18. Scassellati C, Galoforo AC, Bonvicini C, Esposito C, Ricevuti G. Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Ageing Res Rev. 2020;63:101138. [DOI] [PMC free article] [PubMed] [Google Scholar]

19. Clavo B, Perez JL, Lopez L, et al. Ozone therapy for tumor oxygenation: a pilot study. Evid Based Complement Alternat Med. 2004;1(1):93‐98. [DOI] [PMC free article] [PubMed] [Google Scholar]

20. Gencer‐Atalay K, Sahin T. Could ozone therapy be used to prevent COVID‐19? Marmara Med J. 2022;35(2):196‐201. [Google Scholar]

21. Zhang J, Guan M, Xie C, Luo X, Zhang Q, Xue Y. Increased growth factors play a role in wound healing promoted by noninvasive oxygen‐ozone therapy in diabetic patients with foot ulcers. Oxidative Med Cell Longev. 2014;2014: 273475:1‐8. [DOI] [PMC free article] [PubMed] [Google Scholar]

22. Bocci V. Is it true that ozone is always toxic? The end of a dogma. Toxicol Appl Pharmacol. 2006;216(3):493‐504. [DOI] [PubMed] [Google Scholar]

23. Galie M, Covi V, Tabaracci G, Malatesta M. The role of Nrf2 in the antioxidant cellular response to medical ozone exposure. Int J Mol Sci. 2019;20(16):4009. [DOI] [PMC free article] [PubMed] [Google Scholar]

24. Zeng J, Lu J. Mechanisms of action involved in ozone‐therapy in skin diseases. Int Immunopharmacol. 2018;56:235‐241. [DOI] [PubMed] [Google Scholar]

25. Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol. 2005;153(6):1096‐1100. [DOI] [PubMed] [Google Scholar]

26. Fernandez J, Fernandez ID, Villar CJ, Lombo F. Combined laser and ozone therapy for onychomycosis in an in vitro and ex vivo model. PLoS One. 2021;16(6):e0253979. [DOI] [PMC free article] [PubMed] [Google Scholar]

27. Lu J, Fu Z, Liu S, et al. Safety evaluation for medical ozone oil on skin. Zhong nan da xue xue bao. Yi Xue Ban = J Cent South Univ Med Sci. 2018;43(2):131‐138. [DOI] [PubMed] [Google Scholar]

28. Valacchi G, Lim Y, Belmonte G, et al. Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice. Wound Repair Regen. 2011;19(1):107‐115. [DOI] [PubMed] [Google Scholar]

29. Patel PV, Kumar V, Kumar S, Gd V, Patel A. Therapeutic effect of topical ozonated oil on the epithelial healing of palatal wound sites: a planimetrical and cytological study. J Investig Clin Dent. 2011;2(4):248‐258. [DOI] [PubMed] [Google Scholar]

30. di Paolo N, Bocci V, Cappelletti F, Petrini G, Gaggiotti E. Necrotizing fasciitis successfully treated with extracorporeal blood oxygenation and ozonization (EBOO). Int J Artif Organs. 2002;25(12):1194‐1198. [DOI] [PubMed] [Google Scholar]

31. Song M, Zeng Q, Xiang Y, et al. The antibacterial effect of topical ozone on the treatment of MRSA skin infection. Mol Med Rep. 2018;17(2):2449‐2455. [DOI] [PMC free article] [PubMed] [Google Scholar]

32. Ouf SA, Moussa TA, Abd‐Elmegeed AM, Eltahlawy SR. Anti‐fungal potential of ozone against some dermatophytes. Braz J Microbiol. 2016;47(3):697‐702. [DOI] [PMC free article] [PubMed] [Google Scholar]

33. Travagli V, Zanardi I, Silvietti A, Bocci V. A physicochemical investigation on the effects of ozone on blood. Int J Biol Macromol. 2007;41(5):504‐511. [DOI] [PubMed] [Google Scholar]

34. Ugazio E, Tullio V, Binello A, Tagliapietra S, Dosio F. Ozonated oils as antimicrobial Systems in Topical Applications. Their characterization, current applications, and advances in improved delivery techniques. Molecules. 2020;25(2):334. [DOI] [PMC free article] [PubMed] [Google Scholar]

35. McClements DJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 2012;8(6):1719‐1729. [Google Scholar]

36. Lucia A, Guzman E. Emulsions containing essential oils, their components or volatile semiochemicals as promising tools for insect pest and pathogen management. Adv Colloid Interf Sci. 2021;287:102330. [DOI] [PubMed] [Google Scholar]

37. Bakry AM, Abbas S, Ali B, et al. Microencapsulation of oils: a comprehensive review of benefits, techniques, and applications. Compr Rev Food Sci Food Saf. 2016;15(1):143‐182. [DOI] [PubMed] [Google Scholar]

38. Ozyildiz F, Karagonlu S, Basal G, Uzel A, Bayraktar O. Micro‐encapsulation of ozonated red pepper seed oil with antimicrobial activity and application to nonwoven fabric. Lett Appl Microbiol. 2013;56(3):168‐179. [DOI] [PubMed] [Google Scholar]

39. Bocci VA, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose‐response relationship. J Transl Med. 2011;9:66. [DOI] [PMC free article] [PubMed] [Google Scholar]

40. Roth A, Elkashif A, Selyamani V, et al. Wearable and flexible ozone generating system for treatment of infected dermal wounds. Front Bioeng Biotechnol. 2020;8:458. [DOI] [PMC free article] [PubMed] [Google Scholar]

41. Clavo B, Rodriguez‐Esparragon F, Rodriguez‐Abreu D, et al. Modulation of oxidative stress by ozone therapy in the prevention and treatment of chemotherapy‐induced toxicity: review and prospects. Antioxidants. 2019;8(12):588. [DOI] [PMC free article] [PubMed] [Google Scholar]

42. Dranguet Vaillant J, Fraga A, Teresa Diaz M, et al. Ozone oxidative postconditioning ameliorates joint damage and decreases pro‐inflammatory cytokine levels and oxidative stress in PG/PS‐induced arthritis in rats. Eur J Pharmacol. 2013;714(1–3):318‐324. [DOI] [PubMed] [Google Scholar]

43. Siniscalco D, Trotta MC, Brigida AL, et al. Intraperitoneal Administration of Oxygen/ozone to rats reduces the pancreatic damage induced by streptozotocin. Biology‐Basel. 2018;7(1):10. [DOI] [PMC free article] [PubMed] [Google Scholar]

44. Kim J, Cha Y‐N, Surh Y‐J. A protective role of nuclear factor‐erythroid 2‐related factor‐2 (Nrf2) in inflammatory disorders. Mutation research‐fundamental and molecular mechanisms of. Mutagenesis. 2010;690(1–2):12‐23. [DOI] [PubMed] [Google Scholar]

45. Galie M, Costanzo M, Nodari A, et al. Mild ozonisation activates antioxidant cell response by the Keap1/Nrf2 dependent pathway. Free Radic Biol Med. 2018;124:114‐121. [DOI] [PubMed] [Google Scholar]

46. Wang L, Chen Z, Liu Y, Du Y, Liu X. Ozone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway. Drug Des Dev Ther. 2018;12:1293‐1301. [DOI] [PMC free article] [PubMed] [Google Scholar]

47. Singh S, Vrishni S, Singh BK, Rahman I, Kakkar P. Nrf2‐ARE stress response mechanism: a control point in oxidative stress‐mediated dysfunctions and chronic inflammatory diseases. Free Radic Res. 2010;44(11):1267‐1288. [DOI] [PubMed] [Google Scholar]

48. Zhang DD. Mechanistic studies of the Nrf2‐Keap1 signaling pathway. Drug Metab Rev. 2006;38(4):769‐789. [DOI] [PubMed] [Google Scholar]

49. Kim AN, Jeon W‐K, Lee JJ, Kim B‐C. Up‐regulation of heme oxygenase‐1 expression through CaMKII‐ERK1/2‐Nrf2 signaling mediates the anti‐inflammatory effect of bisdemethoxycurcumin in LPS‐stimulated macrophages. Free Radic Biol Med. 2010;49(3):323‐331. [DOI] [PubMed] [Google Scholar]

50. Ahmed SMU, Luo L, Namani A, Wang XJ, Tang X. Nrf2 signaling pathway: pivotal roles in inflammation. BBA‐Mol Basis Dis. 2017;1863(2):585‐597. [DOI] [PubMed] [Google Scholar]

51. Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP. Cerebral mitochondrial function and cognitive performance during aging: a longitudinal study in NMRI mice. Oxidative Med Cell Longev. 2020;2020:1‐12. [DOI] [PMC free article] [PubMed] [Google Scholar]

52. Meng W, Xu Y, Li D, et al. Ozone protects rat heart against ischemia‐reperfusion injury: a role for oxidative preconditioning in attenuating mitochondrial injury. Biomed Pharmacother. 2017;88:1090‐1097. [DOI] [PubMed] [Google Scholar]

53. Costanzo M, Boschi F, Carton F, et al. Low ozone concentrations promote adipogenesis in human adipose‐derived adult stem cells. Eur J Histochem. 2018;62(3):253‐256. [DOI] [PMC free article] [PubMed] [Google Scholar]

54. Quinn PMJ, Moreira PI, Ambrosio AF, Alves CH. PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. Acta Neuropathol Commun. 2020;8(1):189. [DOI] [PMC free article] [PubMed] [Google Scholar]

55. Zhu J, Wang KZQ, Chu CT. After the banquet mitochondrial biogenesis, mitophagy, and cell survival. Autophagy. 2013;9(11):1663‐1676. [DOI] [PMC free article] [PubMed] [Google Scholar]

56. Barodia SK, Creed RB, Goldberg MS. Parkin and PINK1 functions in oxidative stress and neurodegeneration. Brain Res Bull. 2017;133:51‐59. [DOI] [PMC free article] [PubMed] [Google Scholar]

57. Jin SM, Youle RJ. PINK1‐and Parkin‐mediated mitophagy at a glance. J Cell Sci. 2012;125(4):795‐799. [DOI] [PMC free article] [PubMed] [Google Scholar]

58. Bocci V, Paulesu L. Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes. Haematologica. 1990;75(6):510‐515. [PubMed] [Google Scholar]

59. Kucuksezer UC, Zekiroglu E, Kasapoglu N, et al. A stimulatory role of ozone exposure on human natural killer cells. Immunol Investig. 2014;43(1):1‐12. [DOI] [PubMed] [Google Scholar]

60. Peden DB. The role of oxidative stress and innate immunity in O‐3 and endotoxin‐induced human allergic airway disease. Immunol Rev. 2011;242:91‐105. [DOI] [PubMed] [Google Scholar]

61. Thiele JJ, Traber MG, Re R, et al. Macromolecular carbonyls in human stratum corneum: a biomarker for environmental oxidant exposure? FEBS Lett. 1998;422(3):403‐406. [DOI] [PubMed] [Google Scholar]

62. Delgado‐Roche L, Riera‐Romo M, Mesta F, et al. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro‐inflammatory cytokines in multiple sclerosis patients. Eur J Pharmacol. 2017;811:148‐154. [DOI] [PubMed] [Google Scholar]

63. Kafoury RM, Hernandez JM, Lasky JA, Toscano WA Jr, Friedman M. Activation of transcription factor IL‐6 (NF‐IL‐6) and nuclear factor‐kappa B (NF‐kappa B) by lipid ozonation products is crucial to interleukin‐8 gene expression in human airway epithelial cells. Environ Toxicol. 2007;22(2):159‐168. [DOI] [PubMed] [Google Scholar]

64. Yan S, Xu Z, Lou F, et al. NF‐kappa B‐induced microRNA‐31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015;6:7652. [DOI] [PMC free article] [PubMed] [Google Scholar]

65. Hara‐Chikuma M, Satooka H, Watanabe S, et al. Aquaporin‐3‐mediated hydrogen peroxide transport is required for NF‐kappa B signalling in keratinocytes and development of psoriasis. Nat Commun. 2015;6:7454. [DOI] [PMC free article] [PubMed] [Google Scholar]

66. Hess S, Gallert C. Sensitivity of antibiotic resistant and antibiotic susceptible Escherichia coli, enterococcus and staphylococcus strains against ozone. J Water Health. 2015;13(4):1020‐1028. [DOI] [PubMed] [Google Scholar]

67. Chen L, Wen YM. The role of bacterial biofilm in persistent infections and control strategies. Int J Oral Sci. 2011;3(2):66‐73. [DOI] [PMC free article] [PubMed] [Google Scholar]

68. Sharma M, Hudson JB. Ozone gas is an effective and practical antibacterial agent. Am J Infect Control. 2008;36(8):559‐563. [DOI] [PubMed] [Google Scholar]

69. Paraskeva P, Graham NJD. Ozonation of municipal wastewater effluents. Water Environ Res. 2002;74(6):569‐581. [DOI] [PubMed] [Google Scholar]

70. Rangel K, Cabral FO, Lechuga GC, et al. Potent activity of a high concentration of chemical ozone against antibiotic‐resistant bacteria. Molecules. 2022;27(13):3998. [DOI] [PMC free article] [PubMed] [Google Scholar]

71. Choudhury B, Portugal S, Mastanaiah N, Johnson JA, Roy S. Inactivation of Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus in an open water system with ozone generated by a compact, atmospheric DBD plasma reactor. Sci Rep. 2018;8:17573. [DOI] [PMC free article] [PubMed] [Google Scholar]

72. Gulmen S, Kurtoglu T, Meteoglu I, Kaya S, Okutan H. Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant Staphylococcus aureus mediastinitis. J Surg Res. 2013;185(1):64‐69. [DOI] [PubMed] [Google Scholar]

73. Silva V, Peirone C, Amaral JS, et al. High efficacy of ozonated oils on the removal of biofilms produced by methicillin‐ResistantStaphylococcus aureus(MRSA) from infected diabetic foot ulcers. Molecules. 2020;25(16):3601. [DOI] [PMC free article] [PubMed] [Google Scholar]

74. de Sanjose S, Brotons M, Pavon MA. The natural history of human papillomavirus infection. Best Pract Res Clin Obstet Gynaecol. 2018;47:2‐13. [DOI] [PubMed] [Google Scholar]

75. Murray BK, Ohmine S, Tomer DP, et al. Virion disruption by ozone‐mediated reactive oxygen species. J Virol Methods. 2008;153(1):74‐77. [DOI] [PubMed] [Google Scholar]

76. Catell F, Giordano S, Bertiond C, et al. Ozone therapy in COVID‐19: a narrative review. Virus Res. 2021;291:198207. [DOI] [PMC free article] [PubMed] [Google Scholar]

77. Abdullah DM, Kabil SL. Ozone therapy alleviates monosodium urate induced acute gouty Ar‐thritis in rats through inhibition of NLRP3 inflammasome. Curr Drug Ther. 2021;16(4):345‐353. [Google Scholar]

78. Ogut E, Armagan K. Evaluation of the potential impact of medical ozone therapy on Covid‐19: a review study. Ozone Sci Eng. 2022. [Google Scholar]

79. Pages M, Kleiber D, Violleau F. Ozonation of three different fungal conidia associated with apple disease: importance of spore surface and membrane phospholipid oxidation. Food Sci Nutr. 2020;8(10):5292‐5297. [DOI] [PMC free article] [PubMed] [Google Scholar]

80. Khatri I, Moger G, Kumar NA. Evaluation of effect of topical ozone therapy on salivary Candidal carriage in oral candidiasis. Indian J Dent Res. 2015;26(2):158‐162. [DOI] [PubMed] [Google Scholar]

81. Chatterjee D, Mukherjee SK. Destruction of phagocytosis‐suppressing activity of aflatoxin B1 by ozone. Lett Appl Microbiol. 1993;17(2):52‐54. [DOI] [PubMed] [Google Scholar]

82. Luo X, Wang R, Wang L, Li Y, Bian Y, Chen Z. Effect of ozone treatment on aflatoxin B‐1 and safety evaluation of ozonized corn. Food Control. 2014;37:171‐176. [Google Scholar]

83. Pai SA, Gagangras SA, Kulkarni SS, Majumdar AS. Potential of ozonated sesame oil to augment wound healing in rats. Indian J Pharm Sci. 2014;76(1):87‐91. [PMC free article] [PubMed] [Google Scholar]

84. Reis FJJ, Correia H, Nagen R, Gomes MK. The use of ozone in high frequency device to treat hand ulcers in leprosy: a case study. Tropical Medicine and Health. 2015;43(3):195‐199. [DOI] [PMC free article] [PubMed] [Google Scholar]

85. Karakaya E, Akdur A, Soy EA, et al. Effect of subcutaneous topical ozone therapy on second‐degree burn wounds in rats: an experimental study. J Burn Care Res. 2021;42(6):1243‐1253. [DOI] [PubMed] [Google Scholar]

86. Thomas DR, Burkemper NM. Aging skin and wound healing preface. Clin Geriatr Med. 2013;29(2):XI‐XX. [DOI] [PubMed] [Google Scholar]

87. Broughton G II, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg. 2006;117(7):12S‐34S. [DOI] [PubMed] [Google Scholar]

88. Valacchi G, Bocci V. Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets. Mediat Inflamm. 1999;8(4–5):205‐209. [DOI] [PMC free article] [PubMed] [Google Scholar]

89. Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219‐229. [DOI] [PMC free article] [PubMed] [Google Scholar]

90. Kim HS, Noh SU, Han YW, et al. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci. 2009;24(3):368‐374. [DOI] [PMC free article] [PubMed] [Google Scholar]

91. Jazwa A, Loboda A, Golda S, et al. Effect of heme and heme oxygenase‐1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes. Free Radic Biol Med. 2006;40(7):1250‐1263. [DOI] [PMC free article] [PubMed] [Google Scholar]

92. Kimmel HM, Grant A, Ditata J. The presence of oxygen in wound healing. Wounds. 2016;28(8):264‐270. [PubMed] [Google Scholar]

93. Xiao W, Tang H, Wu M, et al. Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway. Biosci Rep. 2017;37:BSR20170658. [DOI] [PMC free article] [PubMed] [Google Scholar]

94. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial‐mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178‐196. [DOI] [PMC free article] [PubMed] [Google Scholar]

95. Nakamichi M, Akishima‐Fukasawa Y, Fujisawa C, Mikami T, Onishi K, Akasaka Y. Basic fibroblast growth factor induces angiogenic properties of fibrocytes to stimulate vascular formation during wound healing. Am J Pathol. 2016;186(12):3203‐3216. [DOI] [PubMed] [Google Scholar]

96. Martin P, Leibovich SJ. Inflammatory cells during wound, repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15(11):599‐607. [DOI] [PubMed] [Google Scholar]

97. Xiao W‐R, Wu M, Bi X‐R. Ozone oil promotes wound healing via increasing miR‐21‐5p‐mediated inhibition of RASA1. Wound Repair Regen. 2021;29(3):406‐416. [DOI] [PubMed] [Google Scholar]

98. Li X, Li DQ, Wikstrom JD, et al. MicroRNA‐132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing. Sci Rep. 2017;7:7797. [DOI] [PMC free article] [PubMed] [Google Scholar]

99. Liu XX, Xu YF, Deng YF, Li HL. MicroRNA‐223 regulates cardiac fibrosis after myocardial infarction by targeting RASA1. Cell Physiol Biochem. 2018;46(4):1439‐1454. [DOI] [PubMed] [Google Scholar]

100. O’Sullivan JN, Rea MC, Hill C, Ross RP. Protecting the outside: biological tools to manipulate the skin microbiota. FEMS Microbiol Ecol. 2020;96(6):fiaa085. [DOI] [PubMed] [Google Scholar]

101. Barnard E, Li H. Shaping of cutaneous function by encounters with commensals. J Physiol‐Lond. 2017;595(2):437‐450. [DOI] [PMC free article] [PubMed] [Google Scholar]

102. Liu J, Yan R, Zhong Q, et al. The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin. ISME J. 2015;9(9):2078‐2093. [DOI] [PMC free article] [PubMed] [Google Scholar]

103. Gao Z, Tseng C‐h, Pei Z, Blaser MJ. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A. 2007;104(8):2927‐2932. [DOI] [PMC free article] [PubMed] [Google Scholar]

104. Moles L, Gomez M, Heilig H, et al. Bacterial diversity in meconium of preterm neonates and evolution of their fecal microbiota during the first month of life. PLoS One. 2013;8(6):e66986. [DOI] [PMC free article] [PubMed] [Google Scholar]

105. Dreno B, Dagnelie MA, Khammari A, Corvec S. The skin microbiome: a new actor in inflammatory acne. Am J Clin Dermatol. 2020;21(SUPPL 1):18‐24. [DOI] [PMC free article] [PubMed] [Google Scholar]

106. Picardo M, Ottaviani M. Skin microbiome and skin disease the example of rosacea. J Clin Gastroenterol. 2014;48:S85‐S86. [DOI] [PubMed] [Google Scholar]

107. Li C‐X, You Z‐X, Lin Y‐X, Liu H‐Y, Su J. Skin microbiome differences relate to the grade of acne vulgaris. J Dermatol. 2019;46(9):787‐790. [DOI] [PubMed] [Google Scholar]

108. Thomas CL, Fernandez‐Penas P. The microbiome and atopic eczema: more than skin deep. Australas J Dermatol. 2017;58(1):18‐24. [DOI] [PubMed] [Google Scholar]

109. Williams MR, Gallo RL. The role of the skin microbiome in atopic dermatitis. Curr Allergy Asthma Rep. 2015;15(11):1‐10. [DOI] [PubMed] [Google Scholar]

110. Myers B, Brownstone N, Reddy V, et al. The gut microbiome in psoriasis and psoriatic arthritis. Best Pract Res Clin Rheumatol. 2019;33(6):101494. [DOI] [PubMed] [Google Scholar]

111. Williams MR, Gallo RL. Evidence that human skin microbiome dysbiosis promotes atopic dermatitis. J Investig Dermatol. 2017;137(12):2460‐2461. [DOI] [PMC free article] [PubMed] [Google Scholar]

112. Xiang Y, Lu J, Li F, et al. Bactericidal effect of ozonated camellia oil on Staphylococcus aureus in vitro. Zhong nan da xue xue bao. Yi Xue Ban = J Cent South Univ Med Sci. 2018;43(2):139‐142. [DOI] [PubMed] [Google Scholar]